I'm have exactly the same problem. Build using Maximus XI Hero wifi, 9900kf, rog strix 2080ti, 500d RGB SE case, H150i AIO, Vengeance Pro RGB ram 3200mhz 16x2, Hx850i PSU.
When iCue started to run on startup, it causes a usb disconnecting sound.(Checked the location on USBDeview, Seems like a driver called Corsair USBxp).
If i stated to play games(i tried GTA V on rockstar launcher, origin games, steam games), that's when nightmares came. Random usb disconnection and reconnect happens. Keyboard, mouse, mouse pad and rgb on fans,AIO basically every usb peripherals no matter it is corsair products or not.
I've tried
Clean re-install including delete registry on Windows
Switch the usb 2.0 port on motherboard for AIO, Commander Pro(Even tried with a NZXT internal hub)
Disable Fast boot on BIOS and Windows
Update everything to newest version, even BIOS
Turn off power saving on USB port
Currently i can only solve the problem by deleting iCue, but what's the point of using corsair's rgb product without iCue. A lot of people seems to having this issue for a long time but Corsair seems don't have a fix for it.