I have a profile for one game where I configured one key to press and hold a mouse button. It works as expected, except when I quit the game the mouse is somehow screwed up. Meaning I cant click some things, for example start menu items or buttons in any program/dialog. This started when I updated to the latest iCUE version. With the previous version I had no issues.
To get the Mouse working I pres CTRL-ALT-DEL to bring the "lock screen" up and then ESC to get back to the Desktop.