I have the same mouse, and I run into issues with the forward and back buttons which will randomly stop working, typically a restart fixes it, but that hasnt been working as of late either. I strongly believe its a software issue as well, because like your issue mine comes and goes randomly(at least at this point seems random, might not after a good trouble shooting, or forum reading) but thus far I havent found an answer other than just a software issue. And if thats the case, im hoping Corsair will get it fixed, because I do like corsair products. Physically they are good, durable, well built products, but i have been rather dissappointed with the icue software the past 6 months or so. Let me know if you figure anything out more than i have. I also have reinstalled, restarted service, all of the above. Good luck to ya man