Even a year later! Thanks for that Edit bro! @castlebAby
Been struggling for a bit, everytime like a few minutes after restart/Start, my keyboard and mouse kept going to Red. Was frustrating the heck out of me.
Reinstalled iCue, reinstalled USB drivers. Just for that sneaky MSI DragonCentre/Mystic Light to be taking control. Honestly, didn't even think of any other software.
For someone getting this in 2020 - Check in Dragon Centre under Mystic Light.
Click the Settings wheel on the Mystic Lights tab and just uncheck that pesky "Mystic light will overwrite third party RGB Software after system restart"