Gianluca - I just installed one of these in my ASUS ROG Crosshair VIII Dark Hero, and it fits fine. The motherboard's M.2 heatsink comes off and then the SSD+block go there directly.
I didn't compare temp & performance with the heatsink versus the water cooling block, but the water cooling does keep the SSD drive quite cool (the temps never went above the water loop's own temp).