I made an account to say it's also happening to me. Super frustrating culmination to a new build. I'm using the x570 Prime Pro, like a lot of people, along with the Commander, H100i plat, and the Lighting Node Core (6 QL's hooked up to it).
Since my motherboard only has 2 USB 2.0 headers, when I ordered the parts I figured that I could just hook the H100i and the Node Core up through the Commander. I didn't know about this issue.
I built a few days ago, couldn't get the H100i and the Node Core to show up in icue, and found this thread. Since it seemed like a USB hub was supposed to resolve the issue, and the NZXT was is sold out everywhere, I ordered this one from amazon: https://www.amazon.com/gp/product/B076Q8685Y/
It showed up today and I just installed it, with the H100i and the Node Core hooked up through it. I can see the H100i and the Node Core in iCue now, and I can control them, which is a step better than before.
However, it has not stopped the constant USB disconnects and reconnects and sounds.
In the meantime, this is what I’ve done and it’s made it more manageable:
• Since I wanted a solid white color anyway, I’ve set the fan profiles and lights on my stuff in icue and saved them to hardware profiles so I don’t have to keep icue running all the time. That’s seemed to help.
• Went through my power management options and set it so the computer can’t turn off USB devices. Also did the same in device manager and made it so the computer can’t turn off USB devices to save power.
• Uninstalled Armory crate, since that seemed to mess with things, and just set up motherboard stuff in Aura, then closed it.
• Turned off the usb connect/disconnect sound in windows, since it was driving me insane.
All this to say, I don’t think the problem is fixed, but it’s made it much more tolerable. It still happening occasionally, I think. It’s hard to tell now that I set everything in hardware profiles. But at least the sound isn’t driving me insane anymore.