That's a hardware profile(since you said if you have the SD card looking icon next to the profile name it is such), how did you get the mouse4 button un-greyed?
How come mine isn't??!
I'm assuming since I don't have the SD like icon next to the profile name, mine is in software mode?
Yes but what if you intentionally remap the profile button and had no intentions of switching to the other two profiles on hardware mode? Or better yet, how about an extra dedicated button for this purpose(instead of using up mouse 4 button), like a small circle right in the middle, ok maybe not right in the middle, maybe hidden somewhere so that it's not accidentally pressed whilst gaming...?