That would be a thing to try, but unfortunately it isn't the usb port - it's only been connected to the Intel® Z77 chipset as the asmedia usb ports are 3.0 and have 3.0 usb drives attached to it.
As per my motherboard specs :
Intel® Z77 chipset : *4
4 x USB 3.0 port(s) (2 at back panel, blue, 2 at mid-board)
Intel® Z77 chipset :
8 x USB 2.0 port(s) (4 at back panel, black, 4 at mid-board)
ASMedia® USB 3.0 controller : *4
2 x USB 3.0 port(s) (2 at back panel, blue)
Those 4 ports I marked in red text, have the keyboard K95 / the mouse Scimitar and XBox controller attached to it all next to eachother.
For ****s and gigles at some point I even tried to attach the mouse to my front USB ports, see if that made a difference, they are USB 2.0 too, Intel.
Other suggestion(s)? I'll also repeat, just to make sure - I'm not using CUE at the moment, and mouse is not turning off since. That also means I can't use any of the macro's, but that's currently preferable compared to losing the mouse mid-game.