I got my M65 Pro RGB yesterday and have run into the same problems. I tried using different USB ports, 2, 3, even 3.1 and the pass-through on the Strafe RGB to no luck. I did end up saving the default dpi settings to the mouse itself and then uninstalled the CUE to see if it fixed the problem. It didn't. My current workaround is to leave the DPI on the default 3rd setting (green light on the profile) as this is the feel it was spiking to (I was using 800dpi). Instead I've got my overwatch sensitivity set to 2 to replicate the old 800dpi and 6 sensitivity I was using with my logitech G700s. I have not noticed the dpi shift on my desktop but I haven't played anything besides overwatch since its launch. I will experiment in other games this weekend though.
PS: Someone mentioned monitors as a possible culprit. I doubt it, but just to put the info out there, I'm running mine at 66hz... I take the overclocking where I can.
