Please file the issue with the Tech Support team on the website and provide system specs: CUE settings > advanced report and Logs if applicable.
We'll try to replicate the issue.
I've been using the M65 Pro for a week now using FW-2.02 on SW-1.16.42
I tried Starcraft 2 using DPI setting #3 set at 1800dpi.
This past week I didn't notice DPI changes so I haven't checked in CUE if it changes automatically. I'll try to replicate again, but get the ticket filed and we'll investigate the cause. Please do include in the ticket the motherboard model and USB port being used (USB view is a helpful tool to find the driver associated with the port used).