So I've been having the same problem and have tied (at least my issue) down to whenever anything else is trying to either view readings from the motherboard or take control of any of the RGB bits.
For my situation, I've removed HWInfo64 and MSI Mystic Dragon and since then....I've had no disconnects.
While this clearly isn't an acceptable state to leave this issue and I'm really frustrated that after going for a premium AIO I'm having these issues it does at least appear to be a workaround.
Hope this helps someone else
