After disabling third party access to the Alienware software, I had no problems for a little over 48 hours. To test my theory, I re-enabled the 3rd party access and experienced the same failure as I had previously after about 2 hours. Based on this, I believe my problem was an incompatibility between the CUE software and/or Scimitar mouse using the lighting sync with other 3rd party software that controls lighting schemes in my system.