With linking a profile to a program, it's possible that other programs can steal focus away from a program unintentionally, changing CUE back to the default profile.
(I'll go ahead and say what programs - things like Zorro or CinemaDrape. I'm guessing there are more cases where it could happen though)
I'd like to see an 'ignore program' option somewhere, effectively causing a program to not be visible to CUE, thus not changing back to the default profile. It can be sort of like logic; When this program IS running AND that program is NOT running, use this profile.
(Heck, that's another idea, allow assigning one profile to multiple programs!)