For whatever reason, on my work MacMini, with v3.21 installed Google Chrome locks up the whole systems. Once I uninstalled it the systems returned to working correctly.
Update:
Nevermind. It still locks up, it just takes a little longer. I upgraded to 3.21, uninstalled 3.21, and I’m still having issues with the thing locking up under chrome. Im not sure it’s iCue, but that ever since installing it I can’t use Chrome without the whole system locking up.