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Well, I have the same problem as Pingo, and it is not a isolated to his PC, not isolated to a version of Windows 10, and not isolated to a version of iCUE 'cause I have this problem before the 1903 windows update, and there are other reports around the interwebs about this problem from some time (here/reddit). As Pingo's setup, I have pretty recent components, no CD/DVD drive attached. i9 9900k ASUS ROG Maximus XI HERO Corsair CMR64GX4M4C3200C16 (4 x 16 GB) Corsair H115i PRO Corsair HX850i Samsung 970 Pro SSD 1 TB Seagate Firecuda SSHD 2 TB Western Digital Blue 500 GB - The oldest part from my PC - but doenst make any difference if I swap it out ASUS ROG Strix RTX 2080TI Peripheral devices connected Logitech G413 Logitech G502 Xbox One Controller adapter No other usb device connected The problem, I suspect comes from either a weird combination (misfit) of Asus motherboard and iCUE or a combination of Samsung SSD and iCUE, or Windows screwing something with the drivers but I have stopped Windows from updating drivers. Even if I uninstall completly iCUE and install the new update the same bootloop or "Inaccessible Boot Device" BSOD. I try from time to time after a driver update or motherboard BIOS update to update iCUE and I have to use restore point to revert to the previous version. I forgot to mention that all drivers are up to date, all programs and windows itself, latest BIOS and firmware to all the components except iCUE.