Same problem here, its not a mechanical failure since the buttons still work for the Ripple lighting effect (im using the Cue link system with my Strave rg) been using the mouse for about 2 weeks, got the new keyboard about 2 days ago ( still no problems ) and today i had a windows update and now the side buttons and middel buttons dont work anymore doesnt matter wat key i assign to it (cue still works) i switched back to my naga and returned this thing back to the store.. but im almost 100% sure its a software problem