For the benefit of others (skip to possible cause/solution at the end)...
I have a M65 Pro RGB, got it about 2 weeks ago. Latest CUE software, latest firmware. I was having the exact issue described in this thread - sensitivity would randomly increase for no reason. The only thing that would correct it was to cycle the DPI settings up and down to restore it, or just unplug/replug. This happened anywhere from every 5 minutes or so to sometime 20 or 30 minutes. No real pattern other than it always seemed to happen when I was making very aggressive movements with the mouse. I do not know if this happened with all games, but it definitely happened with Overwatch.
I was basically using default CUE settings. 1000 mhz polling rate, and mouse set at 800 DPI as default. Windows mouse pointer setting was 6, with acceleration turned off.
I tried everything mentioned here and other places, saved profile to mouse and turned off CUE. Set all DPI settings to same value. etc. etc. Nothing worked.
I returned mouse last Friday and got a replacement (same model) - just to see if it was a hardware issue. The new mouse did exactly the same thing.
So backstory done. On to solution...
I use a K65 keyboard with the pass through USB, i.e. the keyboard has 2 USB connectors. The mouse is plugged into the keyboard and the connection passes through to the 2nd USB connector. I had both USB connectors plugged into my case's front USB ports. As a last stab at trying anything that might work (I really like this mouse otherwise) I tried plugging the 2 USB connectors into my motherboards rear USB ports...
Boom. Problem gone.
Hypothesis: This problem is likely due to either poor connection on some USB ports, shoddy wiring on some cases between the case supplied connectors and the motherboard USB headers, or simply having 3 separate jacks between the mouse and the MB (one on the keyboard, one on the case, and one at the MB header). Combine that with the (relatively) high data load the mouse puts on the USB port, and you get occasional USB noise/dropout/crosstalk/whatever and the mouse goes wonky...
Solution: Try plugging DIRECTLY into your motherboards rear USB jacks. No hubs, no case jacks, straight into the MB. If one port doesn't work, try another. Mine works like this using the pass-through USB on the keyboard, but if all else fails try plugging the mouse straight into the MB itself. You'll probably get it to behave doing one of these.
Hope this helps someone.