In case anyone is having this problem. It came back with a vengeance today and nothing I did, reboots reinstall, following Corsairs tutorial for a plugin to detect the motherboard would fix it.
I've just given up and gone back to a much older version of the software, for now, version 3.2.80 Ideally I would have liked to not go back so far. But I couldn't find a newer older version that didn't look like Malware links XD
On the off chance anyone is also having this issue I've linked the post that I was able to download the old software from
http://downloads.corsair.com/Files/CUE/iCUESetup_3.20.80_release.msi
Hopefully Corsair fix this soon as I never had a single problem in ICUE before this