Yeah, I've done a lot of research on the interrupt issue, down to disabling some things in the NIC driver that were suggested by Intel, but nothing has helped. I work in IT and manage an environment of ~150 PC's, so feel like I have a very good reference point for system performance, and a machine with mostly top-tier specs like mine feels sluggish, worse than my workstation at work.
I have the board loaded pretty good - 2 NVMe SSDs, 2 SATA SSD's, dual port NIC, and sound card. I'm going to try stripping it down to just what I need and see if there's a change before trying a fresh OS install.
It feels to me like whatever lag iCue is causing is already there, it's just amplified when iCue is running.