Thank you for your reply.
I thought it might be a bios, chipset driver problem or B450I just too weak, and considering to switch my spec to Viii impact with the new Ryzen 5000 series.
So even Crosshair VIII got this problem?
Your tips to reduce problem just like what I did.
But I really rely on discord overlay.
I would like switching polling rate to 500hz, but I can feel the difference when I scroll and move my mouse at the same time. The scrolling speed slowdown or even not responding.
And 500hz still lagging with ICUE and discord overlay.
If ICUE is not able to work, my dark core se just really a half dead device for me.
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Just noticed that moving my mouse also causing my system slow down when I try to open a folder or application, even not keeping ICUE in background.
So it may be a hardware problem I guess.