Nope, same here.
I once created a macro that presses sa2 when I press space, but that was months ago. It's gone. Now Escape types sa2 for me everytime I use it, which is quite annoying and often leads to items I didn't intend to use in a game and so on.
iCUE 3.23.66 with a K70 RGB
EDIT: Apparently I fixed it! It doesn't occur anymore, even after restarting.
I soft-resetted my keyboard and uninstalled and reinstalled iCUE after a restart. Escape doesn't trigger anything anymore now, even after recreating my different profiles with macros.
Maybe another key now triggers something, but I haven't found any issues yet. Works fine!