The XR5 420mm fits easily in the front even with push/pull on the fans. You can match the front XR5 420mm with up to another XR5 420mm or up to an XR7 360mm in the top.
You won't be able to put anything except fans in the side mount. That includes the XD7. The XD7 will physically fit but the ports for the radiator are blocked off - so you'd not be able to complete the loop.
You won't be able to use the front HDD tray if you have the 420mm - though you could with a 280mm.