I found THIS, and it finally fixed my issues!
Basically, reinstall (the newest version of) iCue from absolute scratch...
Uninstall
Delete Folders
Delete Registry Items
Reboot
Install from scratch.
For what it's worth, my issues were of the keyboard kind...
Specifically, my K95 Platinum would start macros (set to G keys) by typing random keys (normally the F keys or Esc key).
I'm back up and running all of my macros/actions with the G keys, and my other keys (F keys, etc.) are behaving as normal. Huzzah!