stealthycow

I have the same issue as OP on 2.24.50, macro button launching calculator. usually it doesn't work same as OP (application is not focused, after clicked in the taskbar to focus it requires clicking on application window to get full keyboard focus). sometimes it'll work properly, and like OP it seems like if I open up CUE and then close it, it'll work more reliably for a while but then go back to not working.