I want to ask one question for the same situation. I have 280X RGB chassis and i want to set up 6 fans exactly like DevBiker said but at top i have a 240 mm AIO radiator and if i set up 2 bottom as intake and radiator fans as exhaust, i believe that hot air can't go out because radiator prevents air flow. Also i am using GTX 1080 Ti which runs hot. So hot air inside the chassis can cause cpu temperature go higher.
What if i set up front fans as exhaust, aio radiator fans as exhaust and bottom two as intake? Do you think this can be better configuration?